METHADOSE is contraindicated in clients with known or suspected gastrointestinal obstruction, which includes paralytic ileus. The methadone in METHADOSE may trigger spasm with the sphincter of Oddi.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​�